منابع مشابه
Protein design is NP-hard.
Biologists working in the area of computational protein design have never doubted the seriousness of the algorithmic challenges that face them in attempting in silico sequence selection. It turns out that in the language of the computer science community, this discrete optimization problem is NP-hard. The purpose of this paper is to explain the context of this observation, to provide a simple i...
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Proteins are biological macromolecules made of a chain of simple molecules called aminoacids. The three-dimensional folding of a protein greatly determines its function. Due to the combinatorial nature of the space of possible protein spatial conformations, computer-aided protein study is a major research field in bioinformatics. The problem of computational protein design aims at finding the b...
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We prove that playing Candy Crush to achieve a given score in a fixed number of swaps is NP-hard.
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Human genomes consist of pairs of homologous chromosomes, one of which is inherited from the mother and the other from the father. Species, such as human, with pairs of homologous chromosomes are called diploid. Sequence analysis literature is, however, almost solely built under the model of a single haplotype sequence representing a species. This fundamental choice is apparently due to the hug...
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 2002
ISSN: 1741-0134,1741-0126
DOI: 10.1093/protein/15.10.779